Ijms Free Full Text Targeting Dna Damage Response And Immune Abstract. deficiency in dna damage response (ddr) genes leads to impaired dna repair functions that will induce genomic instability and facilitate cancer development. however, alterations of ddr genes can serve as biomarkers for the selection of suitable patients to receive specific therapeutics, such as immune checkpoint blockade (icb) therapy. Wang et al. summarize the main dna repair mechanisms and the involvement of parp1 in recognition and dna damage response. the review is carefully written and contains all relevant information. this reviewers have only a comments: there are overlapping, alternative and or redundant dna repair pathways. however, the timing in the cell cycle.
Ijms Free Full Text Targeting Dna Damage Response And Immune Point 2: mechanism of dna damage response. the detailed description of each single dna repair mechanism pathway of genome maintenance is very simplistic and limited to very basic information. i would suggest the inclusion of information about differences and similarities, which might help to explain their tissue dependence. Dna damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. the dna damage response (ddr), in turn, coordinates dna damage checkpoint activation and promotes the removal of dna lesions. in recent years, several studies have shown how the ddr and the immune system are tightly. As a result of various stresses, lesions caused by dna damaging agents occur constantly in each cell of the human body. generally, dna damage is recognized and repaired by the dna damage response (ddr) machinery, and the cells survive. when repair fails, the genomic integrity of the cell is disrupted—a hallmark of cancer. in addition, the ddr plays a dual role in cancer development and. The review of huang et al., 2022 [11] shows that the dna damage response (ddr) is a valuable target for the development of anti cancer therapies. although deficiency in ddr genes induces genomic.
Ijms Free Full Text Targeting Dna Damage Response And Immune As a result of various stresses, lesions caused by dna damaging agents occur constantly in each cell of the human body. generally, dna damage is recognized and repaired by the dna damage response (ddr) machinery, and the cells survive. when repair fails, the genomic integrity of the cell is disrupted—a hallmark of cancer. in addition, the ddr plays a dual role in cancer development and. The review of huang et al., 2022 [11] shows that the dna damage response (ddr) is a valuable target for the development of anti cancer therapies. although deficiency in ddr genes induces genomic. 1. introduction. one of the major hallmarks of cancer is genome instability resulting from dna damage caused by external insults and malfunctions in the cell’s dna damage response (ddr) mechanisms [ 1, 2 ]. both external insults such as uv radiation and cigarette smoke and endogenous insults such as reactive oxygen species (ros) can lead to. Dna damage repair (ddr) pathways play an essential role in maintaining genomic integrity. ddr dysfunction leads to accumulated dna damage, predisposition to cancer, and high sensitivity to chemotherapy and radiotherapy. recent studies have demonstrated that ddr status is associated with response to immune checkpoint inhibitors (icis).
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